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apalutamide will decrease the level or result of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Keep away from or Use Alternate Drug. Coadministration of apalutamide, a strong CYP2C19 inducer, with prescription drugs which have been CYP2C19 substrates may end up in decrease publicity to these medicines.enasidenib will enhance the degree o